Anaphase in budding yeast is triggered by cleavage of the central subunit, Scc1, of the chromosomal cohesin complex by the protease separase. Here we show that separase also cleaves the ...

The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis by targeting cyclin B and securin for ...

What am I looking at? These images show a single cell in the middle dividing into two so-called daughter cells. The stage of the cell division process represented here is called anaphase. In these ...

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...

Oncotarget published "NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells" which reported that peripheral T-cell lymphoma is characterized by ...