How the proteins in our bodies bind together to form protein complexes plays a critical role in numerous cell ...

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs. In recent years, models like ...

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a ...

The model also predicts the binding mechanism (non-covalent interactions) between the drug and the target protein. The core innovation of this technology lies in its "simultaneous design" approach.

To generate the training data, the genome of A. thaliana was initially split into non-overlapping 250 bp windows, which were labelled based on overlap with TF families. These labels represented the ...